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Press Release

Dr. Vagnini's Health & Longevity E-Report

November 2005

Heart Disease and Alzheimer's

What's the Connection?

In a nutshell . . . whatever you do to lower the risk of heart disease – control blood pressure and weight, exercise, lower cholesterol, quit smoking – will also protect you against developing dementia and/or Alzheimer’s disease. That’s been proven in research conducted among 9000 adults in a study sponsored by Kaiser Permanente in California. Study findings indicate that each of the cardiovascular risk factors we are all familiar with was a predictor of dementia: Those identified in the study with diabetes were 46 % more likely to develop dementia; those with high cholesterol were 42 % more likely; people who smoked were 26% more likely, and those who had hypertension were 24 % more likely to develop dementia in later years. And when researchers looked at a combination of the risk factors, they found the risk for dementia increased from 27 % for one risk factor to 237 % for having all four risk factors, compared with having no risk factors at all. That means you are more than twice as likely to suffer dementia if you have all of these risk factors.

Five Questions and Answers about Alzheimer's Risk and Pervention.

1. How does exercise lower the risk of Alzheimer’s disease?
The researchers don’t know exactly how exercise works to lower A.D. risk, but like the effect of exercise on heart disease risk, exercise increases blood flow and counters arterial plaques, which are a factor in A.D. It’s been proven that people on a vigorous exercise program will significantly reduce their risk of dementia. Alzheimer’s is a type of dementia.
   
2. How early in life might Alzheimer’s Disease strike?
A.D. is a progressive disease. It is usually in late life that symptoms are recognized. Medical authorities estimate that 50% of the population over 85 has some form of dementia. If the disease develops rapidly in an individual case, it could be diagnosed as early as in the 50s. And in such a case there is probably a genetic factor involved.
   
3. Can Alzheimer’s Disease be diagnosed in a visit to the doctor?
The diagnosis of A.D. is made by exclusion; that is, by ruling out other causes of the patient’s symptoms, such as stroke or depression. The MMSE (Mini Mental State Exam) is a single page test administered orally in the doctor’s office. It is widely used to assess cognitive impairment. If dementia is suspected, the patient is referred for a radiological imaging of the brain – a PET scan, which can be more conclusive.
   
4. What is the distinction between Alzheimer’s Disease and dementia?
A.D. is a form of dementia. There are other forms, but Alzheimer’s is the most common and the most lethal, and it progresses to death. All are neurological disorders of the brain. Some of the other forms can be treated successfully. The definitive diagnosis of A.D. can only be made in an autopsy.
   
5. What can you do in the doctor’s office for someone at risk for or suspected of Alzheimer’s Disease?
Because we know more about A.D., about some nutritional factors involved, about lifestyle therapies that work to prevent it, and because there are improved diagnostic methods for diagnosing it, it is important in clinical practice to begin preventive evaluations.

Alzheimer’s/Dementia Evaluation Program

A number of cognitive impairment conditions are seen in a cardiovascular practice. They may be the result of stroke or the effect of cerebral vascular disease or of untreated hypertension. All of these conditions call for a neurological assessment. It is important to be aware of the possibility of A.D. in an early stage. You hear patients speak of a “senior moment.” Not good.

So far drugs have not been successful in treating A.D. But there are prudent preventive steps that can be taken. Keeping the brain active through reading and mental exercise will ward off or slow down the disease. Dr. David Perlmutter, renowned neurologist and author of a bestseller, The Better Brain Book, argues that we should not give up on finding a cure; in his research he has found antioxidant nutrients C vitamins E to be effective in warding off dementia. Glutathione, a master anti-oxidant protein obtained in fruits and vegetables, enhances brain function. It can also be taken as a food supplement as well as administered intravenously. Gingko biloba has been reported to slow down A.D. High homocysteine is a severe risk factor. These and many more findings from today’s research in functional neurology give the impetus to the Center’s Alzheimer’s /Dementia Evaluation Program.

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Sobering News about Obesity

Just when we thought we couldn't get any fatter, a new study suggests that over the long haul, 9 out of 10 men and 7 out of 10 women will become overweight. Even if you are one of the lucky few who made it to middle age without getting fat, don't congratulate yourself; keep watching that waistline. Half of the men and women in the study who had made it well into adulthood without a weight problem ultimately became overweight. A third of those women and a quarter of the men became obese. "You cannot become complacent, because you are always at risk of becoming overweight," said Ramachandran Vasan, an associate professor of medicine at Boston University and the study's lead author. He and other researchers studied data gathered from 4000 white adults over 30 years. Participants were between the ages of 30 and 59 at the start, and were examined every four years. By the end of the study, more than 1 in 3 had become obese. The study defined obesity as a body mass index of more than 30.The findings, published the Annals of Internal Medicine, show that obesity may be a greater problem than indicated by studies that only look at a cross-section of the population at one point in time. Those so-called "snapshots" of obesity have found about 6 in 10 are overweight and about 1 in 3 are obese. Check that same sample in 10 years and you will find more overweight and more obesity. These latest findings re-emphasize that people must continually watch their weight.

[Reprinted with edits from the weblog: straightfromthedoc.com].

 
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